Both the RS 6 and AMG E-Class Wagon have child safety locks to prevent children from opening the rear doors. The RS 6 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The AMG E-Class Wagon’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Audi RS 6 has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags help prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The AMG E-Class Wagon doesn’t offer a front passenger side knee airbag.
A passive infrared night vision system optional on the RS 6 helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard. The AMG E-Class Wagon doesn’t offer a night vision system.
The RS 6’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the AMG E-Class Wagon.
The Audi RS 6’s rear backup camera has a standard washer for maintaining a clear view under various conditions. In contrast, the Mercedes AMG E-Class Wagon does not offer a rear camera washer, meaning its effectiveness relies on manual cleaning by the user when necessary.
Both the RS 6 and the AMG E-Class Wagon have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, around view monitors, driver alert monitors, available blind spot warning systems and rear cross-path warning.

